Release date: 2007-11-09
Alpha-fetoprotein heterogeneity in the pre-existing early warning of liver cancer According to the study of Wang Yongzhong et al., Chinese Journal of Experimental and Clinical Virology, the abnormality of alpha-fetoprotein heterogeneity (AFP-L3%) is important for early warning of liver cancer. Signal, the study used a rapid device developed by Beijing Thermal Biotechnology Co., Ltd. to separate and detect alpha-fetoprotein heterogeneous body (AFP-L3%), and tracked 8 cases of AFP-L 3% positive non-hepatoma patients (images were not found) The discharge was diagnosed as chronic hepatitis or cirrhosis. The results showed that after 3-12 months, these patients diagnosed with non-liver cancer at the time of discharge were diagnosed as liver cancer, indicating that AFP-L3% abnormality is an important early warning signal for liver cancer. In addition, a comparative study of AFP-L3% in serum of patients with various liver diseases showed that the coincidence rates of AFP and AFP-L3% as indicators for diagnosis of liver cancer in all patients with liver disease were 70.2% and 85%, respectively. The specificity of fetal protein heterogenes is as high as 97%. 2. Primary liver cancer HCC is a common malignant tumor in China. It is generally found in the middle and late stages. The recurrence rate after surgical resection is high, and the five-year survival rate is low. It is called the “king of cancerâ€. The best way to improve survival is early diagnosis. Early treatment. At present, the most important biological indicator for early diagnosis of liver cancer is alpha-fetoprotein, but the accuracy of alpha-fetoprotein is low, and it is also produced in some benign liver diseases. The alpha-fetoprotein heterogeneous AFP-L3 is specifically produced by exacerbated cancer cells and contains a specific sugar chain, which can specifically predict the occurrence of liver cancer. Studies at home and abroad have shown that the alpha-fetoprotein heterogeneous AFP-L3 content is increased by more than 10%, and the risk of developing hepatocellular carcinoma is extremely increased, while benign liver disease does not contain the abnormal alpha-fetoprotein component of the sugar chain. Compared with ultrasound imaging technology, it can be detected in hepatitis and cirrhosis 12 months in advance, which plays an effective early warning role, and the identification effect on benign liver disease is more than 95%, which is called the biological diagnosis index of a new generation of liver cancer. ——Shanghai Medical Device Industry Association
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