Blood test can monitor myocardial cell death
April 26, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];According to a medical paper published by the British journal Nature Communications, scientists have discovered a non-invasive method for detecting myocardial cell death. By measuring circulating free DNA released by dying cardiomyocytes, it is possible to diagnose and monitor myocardial diseases associated with cell death, such as myocardial infarction (heart disease) and sepsis, which is highly sensitive and highly specific.
The original driving force of human blood circulation comes from the contraction and relaxation of the heart, but various pathogenic factors, such as infection, element deficiency, poisoning, severe and persistent ischemia, can directly cause the death of cardiomyocytes, thereby causing the systolic and dysfunction of the myocardium. And eventually lead to disease. Among them, myocardial infarction is myocardial necrosis caused by acute coronary artery ischemia and hypoxia. The survey shows that about 1.5 million people have myocardial infarction every year in the United States, and Asian countries have also shown an obvious upward trend in recent years. Septicemia is a disease. Bacterial or conditional pathogens invade the blood circulation, and the acute systemic infection caused by growth and reproduction of toxins can cause pericarditis or endocarditis.
This time, a team of scientists at the Hadassah Medical School of the Hebrew University of Israel discovered a methylation marker in human cardiomyocyte DNA and developed a method for detecting the marker in the blood.
Studies have shown that this method has high sensitivity and high specificity, can diagnose patients with heart disease, the effect is similar to the detection of troponin levels in the blood - this is the gold standard for clinical detection of heart tissue damage. In the plasma of patients with sepsis, the level of cardiac-specific free DNA was significantly increased, indicating a large-scale death of myocardial cells in patients. Compared with troponin, this newly discovered marker is more indicative of short-term mortality due to sepsis.
The researchers said that although the association between circulating free DNA and cell death needs to be fully documented, scientists believe that the new method may complement the known biomarkers of cardiac damage and hope to help clinicians distinguish cardiomyocytes. Death and reversible cell damage.
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