Induced pluripotent stem cells are a landmark innovation in the international life sciences, requiring the reprogramming of somatic cells to stem cells through the expression of specific genes. However, an article published on Stem Cell on March 16 reported that a team from the University of Buffalo in the United States has shown that adult skin cells can be transformed into neural crest cells (a type of stem cells) without genetic modification. These stem cells can be produced. Other cells present in the spinal cord and brain.
This study suggests that human epidermal keratinocytes can be reprogrammed into neural crest cells in response to fibroblast growth factor 2 and insulin-like growth factor 1 signaling. The reprogrammed neural crest cells can be smooth muscle cells, melanocytes, Schwann cells or neurons.
Keratinocyte-derived neural crest stem cells have been transformed into neurons
The practical implications may be very important, from studying genetic diseases to producing possible regenerative therapies from the patient's own cells.
Corresponding author Stelios T. Professor Andreadis said: "This has great potential for medical applications because you only need a skin biopsy. We can genetically culture and reprogram cells without genetic modification. Therefore, the patient's autologous cells can be used to treat destructiveness. Neurogenic disease, the current treatment of this disease is blocked by the lack of readily available cell sources."
Zhuhai Mingke Electronics Technology Co., Ltd , https://www.zhmkdz-electronics.com