Release date: 2010-08-20
Japanese researchers published a paper in the August 17 issue of the American Journal of Clinical Examination. In animal experiments, using neural stem cells and anti-epileptic drugs, the nerve cells of rats with spinal cord injury are effectively regenerated and the walking ability is restored. .
In previous animal experiments, researchers at the University of Science and Technology of Nara, Japan and Kagoshima University tried to repair damaged nerves by transplanting induced pluripotent stem cells (iPS cells) into mice, but stem cells developed into nerve cells. The probability is less than 1%.
Later, the researchers found that the antiepileptic drug valproic acid can change the genetic structure of neural stem cells, thereby efficiently forming nerve cells. They transplanted neural stem cells collected from the brains of other experimental rat fetuses to rats whose hind limbs were unconscious due to spinal cord injury, and injected valproic acid into the rats for one week. After 6 weeks, 15 of the 21 rats were able to walk again; the remaining 6 symptoms were greatly improved.
If the neural cells developed by the transplanted stem cells are removed, the rats will lose their ability to walk again, which proves that the transplanted stem cells exert a direct effect, and the experimental mice reconstruct the neural network. Transplantation of stem cells followed by valproic acid increases the probability that stem cells develop into nerve cells to about 20%.
The researchers named the technique "HINT", and will use primates for experiments in the future, hoping to be used early in clinical treatment.
Professor Nakajima Nakajima of the research team pointed out: "This is the first attempt in the world to combine stem cells and anti-epileptic drugs. This method is not only suitable for spinal cord injury, but may also be used to treat strokes associated with nerve damage. Jinsen's syndrome, Alzheimer's disease, etc." (Blue Jianzhong)
Source: China Medical Network
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