Release date: 2008-10-20
Premixed liquid bandages Bandages are one of the largest medical hygienic materials in hospitals. Conventional bandages are processed from cotton into strips or gauze strips and then sterilized, but the handling of used and stained old bandages is a major problem. With the strengthening of environmental awareness and energy conservation, cotton bandages have become less and less suitable for clinical needs. Under this circumstance, a new type of “liquid bandage†meeting the requirements of environmental protection and energy conservation came into being, and quickly became a new type of sanitary material in the 21st century. Because it is a new material for military and civilian use, it has broad application prospects and huge market growth space, so foreign health materials science field is competing to develop, and China's health materials science community is also accelerating the development of domestic liquid bandages, in order to catch up with foreign advanced Level.
The need for field care to promote research and development The concept of liquid bandages began in the mid-1980s. At that time, foreign scholars dissolved a natural polysaccharide, chitosan (ie, chitin), into acetic acid to obtain a gelatinous substance. Spraying this gelatinous substance on the hands or body forms a protective film - this is the prototype of the liquid bandage. According to reports, DuPont also developed "artificial skin" based on this principle.
Chitosan not only has a film-forming effect, but more importantly, it is a natural polysaccharide substance, which is very safe to the human body and has an excellent antibacterial effect. However, the researchers later found that chitosan also has some shortcomings: first, the film formation time is too long (it takes more than ten hours); second, the film is airtight and easy to peel off. Therefore, the process of developing liquid bandages using chitosan as a raw material has been stalled. Over the years, researchers have attempted to use various cellulose esters, such as carboxymethyl cellulose (CMC), hypromellose (HPMC) and other processing liquid bandages, but have not been successful.
Although the early development of liquid bandages was not satisfactory, it provided useful experience and lessons for later development work. With the rapid development of life sciences and the advancement of materials science, in the 21st century, the enthusiasm of Western countries to develop new liquid bandages has never been higher. Among them, the most enthusiastic development of liquid bandage-like sanitary materials is the US military medical research institution.
Since 1999, the US military has been fighting in countries such as Afghanistan and Iraq, and the most needed for ambulance wounded soldiers in the field is hemostasis materials. The guerrillas in Afghanistan and Iraq are used to dealing with US military patrols by placing roadside bombs. Once a bomb explodes, the soldiers who are bombed often suffer multiple injuries, and traditional cotton bandages are difficult to stop bleeding and are no longer suitable for modern guerrilla warfare. need. Under this circumstance, the researchers believe that the development of a new type of liquid bandage that is easy to use, can be rapidly coagulated, has the advantages of hemostasis, sterilization, disinfection, and prevention of wound infection, and hopes to meet the ambulance requirements of modern battlefields.
Premixed Liquid Bandage The US Department of Military Health Materials Research Center of Lutger University finally developed this year's new liquid bandage product called “GelSpray Liquid Bandageâ€, which is suitable for field needs, with the support of the US Department of the Army.
According to the research and development personnel, the new liquid bandage consists of two different liquids. The two different components must be pre-mixed and extruded through a needle and coated on the wound through a special double-tube syringe. The liquid bandage can be solidified into a protective film with hemostatic effect in a dozen seconds, and has various effects such as antibacterial, anti-inflammatory, analgesic, preventing wound infection, stopping wound bleeding, etc., so the use is very convenient and the effect is better. Traditional cotton bandages. The new liquid bandage product has been approved for marketing this year by the US Department of the Army and the US Food and Drug Administration (FDA).
Although researchers at Lutger University did not disclose the names of the two major materials used in the development of liquid bandages, according to American Red Cross medical experts, new liquid bandages developed by researchers at Lutger University are likely to use fibrinogen and Thrombin. These two substances are inherent physiological substances in the human body, so they are not foreign bodies to the human body. A feature of fibrinogen is that it quickly solidifies upon encountering thrombin. American Red Cross medical experts analyzed that Lutger University is entirely likely to use these two biological materials to process the liquid bandages that are urgently needed for field rescue. Of course, it is not possible to exclude other antibacterial and anti-inflammatory substances.
Liquid bandages that do not need to be removed Not long ago, scientists at the Massachusetts Institute of Technology and the University of Hong Kong in China jointly developed a new liquid bandage product. According to the researcher, the product is processed from short-chain peptide materials. At present, this new product has been clinically tested in Hong Kong and abroad. Once the trial is successful, China will also have its own liquid bandage-based high-end sanitary materials.
It is known that this new liquid bandage is a clear, transparent gelatinous liquid that can be sprayed directly onto the skin wound through a special syringe. It sprays on the wound within about 15 seconds to solidify into a layer of nano-scale film, which plays a role in stopping bleeding and protecting wounds and wounds. Traditional hemostats, vascular compression methods, hemostatic sponges, etc. usually cannot exert hemostasis in such a short period of time. What is more peculiar is that the new liquid bandage does not need to be removed after the wound is healed, because the liquid bandage uses short-chain polypeptide materials, and the polypeptide is composed of amino acid molecules, so it can be absorbed and utilized by human tissues as nutrients.
Liquid bandages for animals In addition to human liquid bandages, there are also some liquid bandage products on the market in the United States for animal use. For example, last year a US company developed and marketed an aerosol-like hygienic material called “R-7LIQUID BANDAGEâ€. Just spray it on the wounds of pets such as cats and dogs. In just a few seconds, the product can stop bleeding and prevent wound infection. However, the manufacturer did not disclose the raw materials used in the product.
Meridian Animal Health Products, Nebraska, announced on August 20 that it has developed two liquid bandages for animals, namely "Epi-heal" and "Surgi-Lock2oc".
A spokesperson for the company said that the main raw materials for these two liquid bandages for animals are 2-octyl-isocyanate polymer, an inert material that is harmless to living organisms, and contains antibacterial and antiseptic agents. These ingredients are very safe for animals. If these products are sprayed on the cracks or wounds of animal skin, a protective film can be formed in a short time. Studies have shown that these two new liquid bandages have very good adhesion and can not be dropped or peeled off for a long time, so it can promote the healing of animal wounds and prevent infection and inflammation. More importantly, since the animal uses the liquid polymer bandage as the cheapest polymer raw material, the cost and price are not high, and it is suitable for use in the breeding industry.
——Shanghai Medical Device Industry Association
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